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MIT likensa new vibrate capsuleto pledge a glass full of water prior to feeding . dietician advocate the latter as a method for sending signal to your brain to simulate the sensation of being full . The researcher behind the young project further advise it as a future choice to operating theater and GLP-1s . The latter , which let in semaglutides like Ozempic and Wegovy , are both extremely popular and prohibitively expensive , owe in large part to pharma IP laws .
MIT ’s space capsule has seen some laboratory achiever . Giving test beast the tablet 20 moment before eating slenderize their consumption by around 40 % , per the team . Like the chicken feed of water put-on , the capsule stimulates mechanoreceptors , which mail a signal to the brain through the vagus cranial boldness . Once activated , the brain kicks off the output of insulin , GLP-1 , C - peptide and PYY internal secretion , decreasing hungriness while ramping up the digestion process .
“ The behavioral modification is unplumbed , and that ’s using the endogenous system rather than any exogenic therapeutic , ” associate professor Giovanni Traverso notes . “ We have the potential to subdue some of the challenge and costs associated with delivery of biological drugs by modulating the enteric unquiet system . ”
The condensation , which is roughly the size of a standard multi - vitamin , contain a vibrating motor , power by a silver oxide electric battery . After reaching the stomach , gastric acid dissolves the outside layer and completes the circuit , kickstarting the shakiness .
Beyond efficaciousness , the squad is working to determine the system ’s safety . That requires a method acting for ramping up production and eventual human testing . “ At scale , our equipment could be manufactured at a pretty price - effective Leontyne Price point , ” sound out post - doc investigator , Shriya Srinivasan .
Capsule - base technology treatments have been a hot category in recent year , as researchers explore ingestible sensing element and even micro - robotic systems .
